Slay the Spire 2

Boss Database

18 boss encounters with complete mechanics and strategies

Master every boss fight with detailed HP values, complete move sets, attack patterns, phase transitions, and counter strategies. Values in parentheses indicate Ascension-modified stats.

18
Total Bosses
High
Threat Level
Multi-Phase
Some have multiple phases

Attack Patterns

Complete action sequences and decision loops — making every Boss fight predictable

Phase Transitions

HP threshold-triggered behavior changes and strategic turning points

Special Mechanics

Unique abilities, status effects, and interaction rules explained

Ceremonial Beast
BOSS
252 (262)

Ceremonial Beast

5 moves
Stamp
Plow
Beast Cry
+2 more...
Plow X: The first time Ceremonial Beast's HP reaches X or below, it becomes stunned and loses all strength.
Doormaker
BOSS
489 (512)

Doormaker

2 moves
Beam
Get Back In
Starts the fight as Door.
Door
BOSS
155 (165)

Door

3 moves
Dramatic Open
Door Slam
Enforce
Starts with 3*N (4*N) strength
Kaiser Crab
BOSS
Unknown

Kaiser Crab

0 moves
Crusher
BOSS
199 (209)

Crusher

5 moves
Thrash
Enlarging Strike
Bug Sting
+2 more...
Starts with Back Attack and Crab Rage 5.
Rocket
BOSS
189 (199)

Rocket

5 moves
Targeting Reticle
Precision Beam
Charge Up
+2 more...
Starts with Back Attack and Crab Rage 5.
Knowledge Demon
BOSS
379 (399)

Knowledge Demon

4 moves
Curse of Knowledge
Slap
Knowledge Overwhelming
+1 more...
Disintegration X: Take X damage at the end of your turn.
Lagavulin Matriarch
BOSS
222 (233)

Lagavulin Matriarch

4 moves
Slash
Disembowel
Slash 2
+1 more...
Starts with 12 Plating, and sleeps for 3 turns or until losing HP.
Queen
BOSS
400 (419)

Queen

6 moves
Puppet Strings
You Are Mine!
Burn Bright For Me
+3 more...
Starts with a Torch Head Amalgam in play.
Torch Head Amalgam
BOSS
199 (211)

Torch Head Amalgam

3 moves
Tackle
Soul Beam
Weak Tackle
Soul Fysh
BOSS
211 (221)

Soul Fysh

5 moves
Beckon
De-Gas
Gaze
+2 more...
Beckon: 1 cost status, lose 6 HP if it is in hand at the end of turn.
Test Subject #C14
BOSS
Unknown

Test Subject #C14

0 moves
The Insatiable
BOSS
321 (341)

The Insatiable

4 moves
Liquify Ground
Thrash
Lunging Bite
+1 more...
Sandpit X: In X turns, instantly die.
The Kin
BOSS
Unknown

The Kin

0 moves
Kin Priest
BOSS
190 (199)

Kin Priest

4 moves
Orb of Frailty
Orb of Weakness
Beam
+1 more...
Kin Follower
BOSS
58 - 59 (62 - 63)

Kin Follower

3 moves
Quick Slash
Boomerang
Power Dance
Kin Follower is a minion.
Vantom
BOSS
173 (183)

Vantom

4 moves
Ink Blot
Inky Lance
Dismember
+1 more...
Starts with Slippery 9
Waterfall Giant
BOSS
250 (260)

Waterfall Giant

6 moves
Pressurize
Stomp
Ram
+3 more...
Steam Eruption X: After dying, wait 1 turn, then attack for X damage.