Slay the Spire 2
Boss Database
18 boss encounters with complete mechanics and strategies
Master every boss fight with detailed HP values, complete move sets, attack patterns, phase transitions, and counter strategies. Values in parentheses indicate Ascension-modified stats.
18
Total Bosses
High
Threat Level
Multi-Phase
Some have multiple phases
Attack Patterns
Complete action sequences and decision loops — making every Boss fight predictable
Phase Transitions
HP threshold-triggered behavior changes and strategic turning points
Special Mechanics
Unique abilities, status effects, and interaction rules explained

BOSS
252 (262)
Ceremonial Beast
5 moves
Stamp
Plow
Beast Cry
+2 more...Plow X: The first time Ceremonial Beast's HP reaches X or below, it becomes stunned and loses all strength.

BOSS
489 (512)
Doormaker
2 moves
Beam
Get Back In
Starts the fight as Door.

BOSS
155 (165)
Door
3 moves
Dramatic Open
Door Slam
Enforce
Starts with 3*N (4*N) strength

BOSS
Unknown
Kaiser Crab
0 moves

BOSS
199 (209)
Crusher
5 moves
Thrash
Enlarging Strike
Bug Sting
+2 more...Starts with Back Attack and Crab Rage 5.

BOSS
189 (199)
Rocket
5 moves
Targeting Reticle
Precision Beam
Charge Up
+2 more...Starts with Back Attack and Crab Rage 5.

BOSS
379 (399)
Knowledge Demon
4 moves
Curse of Knowledge
Slap
Knowledge Overwhelming
+1 more...Disintegration X: Take X damage at the end of your turn.

BOSS
222 (233)
Lagavulin Matriarch
4 moves
Slash
Disembowel
Slash 2
+1 more...Starts with 12 Plating, and sleeps for 3 turns or until losing HP.

BOSS
400 (419)
Queen
6 moves
Puppet Strings
You Are Mine!
Burn Bright For Me
+3 more...Starts with a Torch Head Amalgam in play.

BOSS
199 (211)
Torch Head Amalgam
3 moves
Tackle
Soul Beam
Weak Tackle

BOSS
211 (221)
Soul Fysh
5 moves
Beckon
De-Gas
Gaze
+2 more...Beckon: 1 cost status, lose 6 HP if it is in hand at the end of turn.

BOSS
Unknown
Test Subject #C14
0 moves

BOSS
321 (341)
The Insatiable
4 moves
Liquify Ground
Thrash
Lunging Bite
+1 more...Sandpit X: In X turns, instantly die.

BOSS
Unknown
The Kin
0 moves

BOSS
190 (199)
Kin Priest
4 moves
Orb of Frailty
Orb of Weakness
Beam
+1 more...
BOSS
58 - 59 (62 - 63)
Kin Follower
3 moves
Quick Slash
Boomerang
Power Dance
Kin Follower is a minion.

BOSS
173 (183)
Vantom
4 moves
Ink Blot
Inky Lance
Dismember
+1 more...Starts with Slippery 9

BOSS
250 (260)
Waterfall Giant
6 moves
Pressurize
Stomp
Ram
+3 more...Steam Eruption X: After dying, wait 1 turn, then attack for X damage.